A Bundibugyo virus disease outbreak in the Democratic Republic of the Congo and Uganda has grown rapidly to 134 confirmed cases with 18 deaths as of late May 2026, with transmission concentrated in DRC's Ituri province and spreading to Uganda's capital region. Security incidents and community resistance in affected areas are hampering outbreak response efforts, while a U.S. medical worker exposed during patient care in DRC tested positive and was transported to Germany for treatment.